The world is a complex system, and understanding it scientifically requires advanced computational resources and approaches. Engineers design the most powerful computers on Earth in order to model and simulate physical systems such as global climate, the expansion of the universe, and the behavior of matter at an atomic level. But today, high performance scientific computing means more than just supercomputers running numerical models, expanding to large-scale data analysis, AI and machine learning, visualization, and distributed and heterogeneous hardware systems.

UChicago CS researchers are changing the face of high performance computing (HPC), creating new computing paradigms at scale for understanding physical, biological, social, and ecological systems and answering the most significant questions facing society. Faculty lead efforts to apply the latest AI and data science approaches for scientific discovery, from computational imaging and spectroscopy to bioinformatics, neuroscience, and agriculture. In these areas, as well as in the development and application of new exascale systems such as Aurora, UChicago CS benefits from a strong partnership with Argonne National Laboratory.

Labs & Groups

Globus Labs

Ian Foster, Kyle Chard
Realizing a world in which all research data are reliably, rapidly, and securely accessible, discoverable, and usable.

Large-Scale Systems Group (LSSG)

Andrew A. Chien
Exploring critical systems research questions underlying sustainable, scalable large-scale systems, including cloud, high performance, edge, and mobile/IoT computing.


Kate Keahey, Haryadi Gunawi
A configurable experimental environment for large-scale edge to cloud research.

Center for Translational Data Science

Robert Grossman
A research center developing the discipline of translational data science and applying to advance biology, medicine, healthcare and environmental research.

Related Faculty

Kyle Chard

Research Associate Professor of Computer Science

Andrew A. Chien

William Eckhardt Distinguished Service Professor of Computer Science

Anshu Dubey

Senior Scientist, CASE Affiliate

Todd Dupont

Professor Emeritus of Computer Science, Mathematics, and the James Franck Institute

Ian Foster

Arthur Holly Compton Distinguished Service Professor of Computer Science

Robert Grossman

Frederick H. Rawson Distinguished Service Professor in Medicine, Computer Science

Rana Hanocka

Assistant Professor of Computer Science

Kate Keahey

Senior Scientist, CASE Affiliate

Gordon Kindlmann

Associate Professor of Computer Science

Rick Stevens

Professor of Computer Science

Rebecca Willett

Professor of Computer Science, Statistics

News & Events

UChicago CS News

Empowering Middle School Girls in Tech: compileHER’s <prompt/HER> Capstone Event

May 20, 2024
UChicago CS News

Haifeng Xu Wins Best Paper Award at Leading AI Conference for Pioneering Research on Mechanism Design for LLMs

May 17, 2024
UChicago CS News

Fred Chong Receives Quantrell Award for Excellence in Teaching

May 16, 2024
UChicago CS News

Unveiling Attention Receipts: Tangible Reflections on Digital Consumption

May 15, 2024
UChicago CS News

NASA to Launch UChicago Undergraduates’ Satellite

May 14, 2024
UChicago CS News

University of Chicago Computer Science Researchers To Present Ten Papers at CHI 2024

May 06, 2024
UChicago CS News

Two UChicago MPCS Students Win the Apple Swift Student Challenge

May 01, 2024
In the News

How Artificial Intelligence Can Transform U.S. Energy Infrastructure

Apr 29, 2024
In the News

Community Data Fellow Stephania Tello Zamudio helps broaden internet access for Illinois residents

Apr 29, 2024
UChicago CS News

Two UChicago CS Students Awarded NSF Graduate Research Fellowship

Apr 24, 2024
UChicago CS News

Non-Unital Noise Adds a New Wrinkle to the Quantum Supremacy Debate

Apr 05, 2024
In the News

The Science of Computer Security: An Interview with Grant Ho, Assistant Professor in Computer Science

Apr 02, 2024
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