Date & Time:
May 8, 2019 1:00 pm – 2:00 pm
Harper Center 219, 5807 S. Woodlawn Ave., Chicago, IL,
05/08/2019 01:00 PM 05/08/2019 02:00 PM America/Chicago Rosemary Braun (Northwestern) – Using Gene Expression to Tell Time Machine Learning Seminar Series Harper Center 219, 5807 S. Woodlawn Ave., Chicago, IL,

Using Gene Expression to Tell Time

Determining the state of an individual’s internal physiological clock has important implications for precision medicine, from diagnosing neurological disorders to optimizing drug delivery. To be useful, such a test must be accurate, minimally burdensome to the patient, and robust to differences in patient protocols, sample collection, and assay technologies. In this talk I will present TimeSignature, a novel machine-learning algorithm to estimate circadian variables from gene expression in human blood. By making use of the high dimensionality of the gene expression measurements and exploiting the periodic nature of the circadian variables we wish to predict, TimeSignature can be applied to samples from disparate studies and yield highly accurate results despite systematic differences between the studies. This generalizability is unique amongst expression-based predictors and addresses a major challenge in the development of robust biomarker tests. This talk will detail the method, present several applications, and discuss our recent work to extend it.

Rosemary Braun

Assistant Professor, Northwestern University

Rosemary Braun (PhD, MPH) is an Assistant Professor in the Division of Biostatistics (Dept of Preventive Medicine, Feinberg School of Medicine) and the Department of Engineering Sciences and Applied Mathematics at Northwestern University. Dr Braun’s overarching research interests are in the development of mathematical and computational methods to elucidate how large-scale biological phenomena emerge from the complex interplay of thousands of microscopic interactions. To this end, her research group develops machine-learning methods for the statistical analysis of high-dimensional omics data; graph-thoretical approaches for modeling the behavior of regulatory networks; and dynamical simulations to study molecular interactions. Recent publications have appeared in PNAS, Nucleic Acids Research, and Bioinformatics. Dr Braun obtained her PhD in Physics in 2004 from the University of Illinois at Urbana Champaign, where she studied the statistical physics of living systems under Klaus Schulten. This was followed by an MPH (Concentration in Biostatistics) at Johns Hopkins in 2006. Prior to joining Northwestern, she was a Postdoctoral Fellow at the National Cancer Institute (2006-2011).

Related News & Events

Students posing at competition
UChicago CS News

UChicago Undergrad Team Places Second Overall In Regionals For World’s Largest Programming Competition

Mar 17, 2023
Haifeng Xu
UChicago CS News

New CS and DSI Faculty Haifeng Xu Brings Strategic Intelligence to NeurIPS 2022

Nov 28, 2022
UChicago CS News

UChicago CS Research Finds New Angle on Database Query Processing with Geometry

Nov 08, 2022
UChicago CS News

Asst. Prof. Aloni Cohen Receives Award For Revealing Flaws in Deidentifying Data

Sep 09, 2022
UChicago CS News

UChicago Hosts NSF Workshop on Frontiers of Quantum Advantage

Aug 15, 2022
UChicago CS News

New 2022-23 Faculty Add Expertise in Linguistics, Visualization, Economics, and Data Science Education

Aug 11, 2022
In the News

UChicago Co-Leads $10 Million NSF Institute on Foundations of Data Science

Aug 09, 2022
In the News

Bill Fefferman Comments on New Standards for Quantum-Proof Cryptography

Jul 07, 2022
UChicago CS News

UChicago London Colloquium Features Data Science, Quantum Research

Jul 01, 2022
UChicago CS News

Faculty Bill Fefferman and Chenhao Tan Receive Google Research Scholar Awards

Jun 21, 2022
UChicago CS News

First-Year PhD Student Co-Authors Outstanding Paper Award Winner at TQC 2022

Apr 28, 2022
In the News

Quanta Magazine Features Prof. Bill Fefferman’s Work on Quantum Algorithms

Jan 20, 2022
arrow-down-largearrow-left-largearrow-right-large-greyarrow-right-large-yellowarrow-right-largearrow-right-smallbutton-arrowclosedocumentfacebookfacet-arrow-down-whitefacet-arrow-downPage 1CheckedCheckedicon-apple-t5backgroundLayer 1icon-google-t5icon-office365-t5icon-outlook-t5backgroundLayer 1icon-outlookcom-t5backgroundLayer 1icon-yahoo-t5backgroundLayer 1internal-yellowinternalintranetlinkedinlinkoutpauseplaypresentationsearch-bluesearchshareslider-arrow-nextslider-arrow-prevtwittervideoyoutube